Mol Cancer Ther 2021; 20: 1462–8 (doi:10.1158/1535-7163.MCT-20-0394)
This international consensus paper provides recommendations based on the experience of the NCI funded PPTP/C (www.ncipptc.org) and the EU funded ITCC-P4 public private partnership (https://www.itccp4.eu/) for the use of cell-based and mouse models for pediatric solid malignancies, as well as guidance on the scope and content of preclinical proof-of-concept data packages to inform clinical development dependent on clinical urgency. These recommendations can serve as a minimal guidance necessary to jumpstart preclinical pediatric research globally.
