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Target Actionability Review: a systematic evaluation of replication stress as a therapeutic target for paediatric solid malignancies

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European Journal of Cancer, 162 (2022): 107-117 (doi:10.1016/j.ejca.2021.11.030)

The 3rd Target Actionability Review (TAR) is published in the…

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The 2nd Target Actionability Review (TAR) on CDK4/6

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The 2nd Target Actionability Review (TAR) on CDK4/6 as drug targets in pediatric cancers has been finalized by authors of the ITCCP4 consortium.
For…

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International Consensus on Minimum Preclinical Testing Requirements for the Development of Innovative Therapies For Children and Adolescents with Cancer

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Mol Cancer Ther 2021; 20: 1462–8 (doi:10.1158/1535-7163.MCT-20-0394)
This international consensus paper provides recommendations based on the…

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Systematic target actionability reviews of preclinical proof-of-concept papers to match targeted drugs to paediatric cancers

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European Journal of Cancer 2020, 130:168-181 (doi:10.1016/j.ejca.2020.01.027)
The methodology for ITCCP4 Target Actionability Review is published as…

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First Target Actionability Review on MDM2 in pediatric cancers published in the European Journal of Cancer

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European Journal of Cancer 2020, 160:168-181 (doi:10.1016/j.ejca.2020.01.027)
For this extensive, systematic literature review the authors identified…

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